Will we see a Dr. Strange Villain on Agents of S.H.I.E.L.D?

It looks like Agent's of S.H.I.E.L.D. is putting the Inhumans on the backburner for a bit and getting into the mystical arts for the fourth season of the show. So far, after three episodes we've been treated to Robbie Reyes' (Gabriel Luna) Ghost Rider who, I think everyone can agree, has restored the faith in the Spirit of Vengeance after Nicholas Cage. And now it seems they are taking it a step further and delving into Dr. Strange territory by introducing an ancient book of magic called the Darkhold. This book according to the comics is also called the Book of Sins written over a billion years ago by what they call an Elder God named Chthon. Apparently the book is so powerful it took the combined magic of Merlin and St. Brendan to contain it. The Book is supposed to channel the influence of Cthon himself. It is a conduit of black magic that gives the user very dark dimensional powers. Clearly writer Gerry Conway and artist Mike Ploog were sowing their Lovecraft oats with this character. Anyway this book has crossed over to many other Marvel characters including Red Sonja, Conan, Mordred and King Arthur, Blade the Marvel Zombies, Dr. Doom, Dracula and of course Dr. Strange, who according to the good book of Marvel, obtained the Darkhold at a certain point as part of his massive library. I feel fairly confident that we won't actually see Cumberbatch show up on the show as Strange but the book may come into his possession in the movie as a tie in from the show. 

The real question is will we see some Dr. Strange villains on the show this year? Robbie Reyes has already alluded a few times to the demon that he sold his soul to. He didn't mention a name but it has to be Mephisto who has tangled with Strange from time to time. Frankly it would be awesome to see some Mindless Ones come about beacause of misuse of the book which would tie in nicely to Dormammu. But even I can acknowledge that would be an insane tie-in given that Dormammu is Dr. Strange's big bad. But I really have enjoyed this turn to the dark mystical side and I've seen a vast improvement in the script and tone of the show since moving it to the 10 pm slot on Tuesday. So if you haven't started watching Agents of S.H.I.E.L.D. you can catch up on the past 3 seasons Netflix and the current 4th season on ABC.